Mar elements are often believed to have low stability, as they can be lost during cell division due to their small size. However, when we compared the frequency of the mar by FISH for GLDC in 9p24.1-carrier HFs at low (p5) (DL3363, 55.0%; DL5459, 54.5%) and high (p20) passage (DL3363, 54.0%; DL5459, 45.5%), we found only minimal decline in extra FISH signals for the GLDC locus in interphase cells (Figure 1G and Table S1).
