Based on the important role of CHN2 in the changes of neuronal compensatory adaptation and substance addiction, we hypothesized that there was a difference in the methylation level of CHN2 gene between MA addicts and normal individuals. With the purpose of finding out the epigenetic mechanism of MA-inducing psychotic disorder, methylight qPCR was used to detect the methylation levels of CHN2 gene in 224 MA addicts and 109 healthy controls.
