have died of opioid overdose. But were they opioid dependent? Did they overdose accidentally, or did they die of suicide? If the latter, were they opioid-exposed prior to the terminal event? When we study peripheral tissues from living subjects, we can have more extensive information about phenotype. There is an additional key consideration if omics results are to have clinical utility: utilization in the clinic depends on measurements being made on tissue that can be derived from living subjects. In the sections below, we focus on two main omics domains investigated with respect to SUD traits. As for GWAS, the general pattern that there are much more data for legal than for illegal SUDs pertains.
