In this 2019 update of g:Profiler we have introduced a complete technical rewrite of our well established service. The new version of g:Profiler toolset provides faster and more intuitive service while keeping the technical robustness, data quality and data update frequency at the same high quality level as before. Since the initial publication in 2007 the controlled vocabularies (e.g. GO) and knowledge bases (e.g. KEGG) have grown considerably in size and new data sources continue to emerge (WikiPathways, DisGeNET) (21,36). By including data about more species, the underlying data has grown by an order of magnitude requiring us to move towards better suited data structures. This new architecture also made it possible to enable users’ own GMT files to be used for enrichment analysis, a request that our users have asked already for a while. We have also implemented a new responsive graphical user interface to improve the user experience. The customisability of the results tables and highlighting options of the Manhattan plot allow users to prepare publication and presentation ready images straight from the website.
