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Chunk #15 — Materials and Methods — fMRI acquisition, processing, and analysis

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Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults.
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Each participant was scanned using a Siemens Trio 3 T scanner. BOLD functional images were acquired with a gradient echo planar imaging (EPI) sequence and covered 34 axial slices (3 mm thick) beginning at the cerebral vertex and encompassing the entire cerebrum and the majority of the cerebellum (TR/TE = 2000/29 ms, FOV = 200×200, matrix = 64×64). All scanning parameters were selected to optimize the quality of the BOLD signal while maintaining a sufficient number of slices to acquire whole-brain data. Before the collection of fMRI data for each participant, we acquired a reference EPI scan that we visually inspected for artifacts (e.g., ghosting) and for good signal across the entire volume of acquisition. The fMRI data from all included participants were cleared of such problems.