with QT interval (Arking et al. 2006; Post et al. 2007). Genome-wide association studies for ECG traits have also revealed pleiotropy: for example, variants in the cardiac sodium channel gene SCN5A, has been associated with across multiple ECG traits (Holm et al. 2010; Jeff et al. 2011; Marroni et al. 2009; Newton-Cheh et al. 2007; Smith et al. 2009). Variants in SCN10A, a gene previously known to play a role in the action potentials in nociceptive nerve fibers (Abrahamsen et al. 2008; Akopian et al. 1999; Zimmermann et al. 2007), have been identified by GWAS for an association with PR and QRS interval (Chambers et al. 2010; Denny et al. 2010; Holm et al. 2010; Pfeufer et al. 2010; Sotoodehnia et al. 2010).
