The imputation server workflow has been integrated into Cloudgene24 to provide a graphical user interface. Cloudgene is a high-level workflow system for Apache Hadoop designed as a web application using Bootstrap, CanJs, and JQuery. On the server side, all necessary resources are implemented in Java using the RESTful web framework Restlet. The Cloudgene API provides methods for the execution and monitoring of MapReduce jobs and can be seen as an additional layer between Hadoop and the client. The imputation server is integrated into Cloudgene using the provided workflow definition language and its plugin interface. On the basis of the workflow information, Cloudgene automatically renders a web form for all required parameters to submit individual jobs to the Cloudgene server. The server communicates and interacts with the Hadoop cluster and receives feedback from currently executing jobs. Client and server communicate by asynchronous HTTP requests (AJAX) with JSON as an interchange format. All transmissions between server and client are encrypted using SSL (Secure Socket Layer).
