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Chunk #61 — Review

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Genome-wide association studies in ADHD.
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are expressed in multiple tissues including brain. A specific role in brain development or functioning has not been reported for either of these genes, though. Additional genes modulating the extracellular matrix are found in all three studies, including HAS3 (Lasky-Su et al. 2008b), SPOCK3 (Neale et al. 2008a), MAN2A2, GPC6 and MMP24 (Lesch et al. 2008). A third interesting overlap is for genes related to potassium-channel function, like the KCNC1 gene reported by Lesch et al. (2008), the KCNIP1 and KCNIP4 genes observed by Neale et al. (2008a)) and the DPP10 finding for total ADHD symptom count (Lasky-Su et al. 2008b).