We observed that MPV SNP rs12485738 (on 3p14.3) was also trans-acting on tropomyosin 1 (TPM1, 15q22.2, p = 9.7×10−9), a gene that is also regulated in cis by another MPV variant (rs11071720 on 15q22.2, p = 1.4×10−13). We observed this for two different expression probes that map within different locations of the TPM1 transcript (probes 5560246 and 610519), and note strong co-expression for these two TPM1 probes with 46 MPV trans-genes (Pearson r>0.19, p<1.0×10−11, including five known coagulation genes). Although several genes reside within the rs11071720 MPV locus, these observations strongly implicate TPM1 as the causal MPV gene.
