alcohol consumption31,32. These findings are also consistent with the PRS analyses in the MVP sample, where both AUDIT-C and AUD PRS were associated with AUDIT-C and AUD phenotypes. Both traits also predicted multiple alcohol-related phenotypes in independent datasets, including alcohol dependence criteria in the Yale-Penn sample. However, there was a smaller effect of AUDIT-C PRS scores than AUD PRS scores on alcohol-related disorders and alcohol dependence. This is in line with findings from the meta-analysis of UKBB and 23andMe data, where the genetic correlation with alcohol dependence was nominally greater for AUDIT-P scores (rg = 0.63) than AUDIT-C scores (rg = 0.33)8.
