The MWM is a standard task where a T, plus or open field maze can be submerged in cloudy water. A platform can then be hidden below the surface, and visual detection of the rodent when swimming in the maze. The animal must swim to explore the maze and find the submerged platform to escape the water in multiple training trials where variables such as latency to the platform, swim speed, and distance traveled to platform can be measured. As described above, the MWM can be adapted for many functions, such as delayed matching-to-place (233), which are readily learned by healthy rodents. However, PNEE rodents exhibit significant impairments on this task [rats: liquid diet GD 1–22 (55, 141, 175) and intubation PND 4–9 (56, 95, 184–186); guinea pigs intubation GD 2–67 (102)].
