Two patterns of results emerged from the 13 regions that had significant LR group or LR by placebo/alcohol condition effects in Table 2, with most of the findings observed for happy faces. First, in 12 of the 13 regions in Table 2, low LR subjects showed a decreasing BOLD response contrast intensity or little change from placebo to alcohol conditions in the inferior and middle frontal gyri, insula, and anterior cingulate. However, for high LR, in nine of the 13 regions the BOLD response contrast increased from placebo to alcohol. These included four of the nine regions with effects for happy faces and the single region for fearful faces. Therefore, while low LR individuals tended to demonstrate little change or a diminished brain response after alcohol relative to placebo, the high LR group showed an increasing response after alcohol compared to placebo. Second, comparisons of low versus high LR groups after placebo revealed that in eight of the 13 regions in Table 2, lower BOLD response contrast was seen for those with low LRs.
