We planned a set of subgroup and sensitivity analyses to assess the effect of clinical and study design effect-modifiers—eg, duration of study, gender, age (children vs adolescents), psychiatric comorbidities, IQ, crossover design, medication status, industry sponsorship, inequalities in doses, risk of bias, and data imputation.30 We restricted the primary analysis to studies using medications within the therapeutic range (as per FDA recommendations, where applicable). Additionally, we investigated effects at different dose regimens in two sets of sensitivity analyses. First, we excluded studies that did not use the FDA-licensed dose (appendix pp 277–79). Second, we included studies in which the dose ranges used were recommended in national or international guidelines or formularies but differed from FDA recom-mendations. Finally, to investigate possible differences between lisdexamfetamine and other amphetamines, we did a post-hoc analysis separating this compound, because lisdexamfetamine is metabolised differently from other amphetamines, which could affect its efficacy and tolerability.45
