We identified three distinct clusters of associated SNPs, on chromosomes 17, 11 and 8 (Fig 2). The two smaller clusters of markers on chromosome 11p15.5 and chromosome 8q21.12 yielded suggestive association with p < 10−6 and 19 markers with p < 10−7 were located either within or close to CCDC42 on chromosomes 17 (Table A in S2 File). The regions on chromosomes 8 and 11 contained a density of markers with p≤3.5 x 10−5 (Table A in S2 File). The genes PXDNL (peroxidasin-like), PCMTD1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1) and ARHGEF10 (Rho guanine nucleotide exchange factor (GEF) 10) all localized to the region on chromosome 8. The markers on chromosome 11 predominantly localized to the gene BRSK2.
