Verification of the growth patterns with respect to the NCANDA adolescents, showed that the significance of areas 4, 23c, and p24’ were stronger than the impact of the cortical folding in estimating the normalized myelin content (see Appendix A.5). Furthermore, the findings were confirmed through a novel longitudinal analysis, which explicitly harmonized the data across visits and was validated using inter- and intra-site human phantom data (see Appendix A.3). Specifically, the significant deceleration of aging effects in the area with significantly greater gains in normalized myelin content (i.e., area 4 [R]) and the significant acceleration of aging effects in areas with significantly smaller gains in normalized myelin content (i.e., areas 23c [R] and p24' [L]) further supports the hypothesis that development is slowing with early adulthood.
