In summary, our study leveraged the largest genetic datasets and various genetic approaches to evaluate the relationship between cannabis phenotypes and psychotic disorders. The present findings support a shared genetic basis, with bidirectional causality, which helps explain the well-established co-occurrence of psychotic disorders and cannabis use. Also, a subgroup of individuals will exhibit a high genetic risk of both developing a psychotic disorder and using cannabis, supporting targeted public health efforts to reduce cannabis use particularly among these high-risk individuals. Identified shared genetic loci may also aid in treatment efforts. Ultimately, these results may help inform public health policies and aid in pursuits of customized care for patients.
