five most connected genes in the adolescence brain regions (Table 3). Note that the ranks of DEGs according to their numbers of connections in the co-expression networks exhibited better correlations in brain regions of the same developmental stage (Table 4). The data indicate that the co-expression networks display greater differences between developmental periods than brain regions, further suggesting that different subsets of the DEGs may play important roles at different periods of brain development.Table 3DEGs or 22q11.2 genes with the most co-expressed genes in different brain regions*Brain RegionEmbryonicAdolescenceDEGs22q11.2DEGs22q11.2FC KIAA1467 CDC45 HERC3 CRKL MAPKAPK3 COMT DDX3X PRODH CHD1L TXNRD2 MTMR7 DGCR6 SEPT2 SLC25A1 ELL2 LZTR1 RFXANK THAP7-AS1 LRRTM3 C22orf29 SC SCAF11 CDC45 PJA2 C22orf39 KHNYN SLC25A1 ZMYM2 MED15 MAPKAPK3 CLDN5 DPP8 PRODH TP53 COMT PDCD6IP HIRA LAMC3 CRKL B4GALT6 TANGO2 SM PLIN3 CDC45 PDCD6IP COMT FGFR2 CRKL HDAC7 DGCR6 RREB1 THAP7-AS1 UBE3C CRKL MAPKAPK3 COMT LRFN5 PRODH MCAM SEPT5 GLRB SLC25A1 TP FGFR2 SLC25A1 MEF2A COMT MAP7D3 CDC45 NRXN1 DGCR6 PLIN3 RANBP1 FBXO45 CRKL MAPKAPK3 SCARF2 PDCD6IP PRODH TP53 SNAP29 MTMR7 SLC25A1 Total MAPKAPK3 CDC45 PDCD6IP PRODH PLIN3 SLC25A1 MTMR7 DGCR6 SCAF11 COMT GLRB COMT *In each stage and region, DEGs or 22q11 deleted genes were ranked according to their numbers
