conditional analyses, male alcohol users were significantly more likely to transition to regular alcohol use, whereas no sex differences were associated with drug use transitions. Reduced risk for black adolescents was significant only in transitions from alcohol use to regular use, from having the opportunity to use drugs to drug use, and from drug use to drug abuse without dependence. Despite lower rates of drug use among other racial/ethnic groups, these adolescents were more likely than white adolescents to transition from use to abuse with dependence. These findings are concordant with previous studies16,17,22,29 demonstrating that stage of previous substance use moderates the role of sociodemographic factors.