in TG (+30%; F(1, 16) = 4.66, p < 0.05). An interaction effect [F(1,16) = 4.66, p < 0.05] revealed a synergy between ethanol and fat in raising TG. This was evident in the considerably larger increase in TG levels in ethanol-drinking rats after the HFD meal (+172%) compared to the LFD meal (+111%). These groups showed no differences in their measures of caloric intake [F(3.16) = 2.29, ns], daily water intake [F(3.16) = 1.91, ns], or 2-h ethanol intake after the meal (0.22 ± 0.11 g/kg for HFD vs. 0.22 ± 0.08 g/kg for LFD). Thus, the only significant difference between these groups was found in their circulating TG levels.