Chunk #11 — METHODS — Genetic Analyses

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Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence.

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In this study, both a quantitative trait, P3 amplitude of the ERP, and a dichotomous variable, alcohol dependence by DSM-IV criteria, were the phenotypes tested. False discovery rate, FDR (Benjamini and Hochberg, 1995; Storey and Tibshirani, 2003), was calculated to correct for multiple comparisons using the method developed by Storey and Tibshirani (2003).