a region being implicated by expression imputation, recapitulating the initial problem. In addition, the lack of large samples of available brain tissues from both patients and healthy donors at appropriate stages of development as yet hampers the wide scale application of this approach, although the CommonMind (http://commonmind.org) and Brainseq25 initiatives are taking strides in this direction (discussed below). It remains the case that each GWAS locus requires careful and bespoke examination (see Geschwind et al this issue26).).
