This work and D.M.E. were supported by a Medical Research Council New Investigator Award (MRC G0800582). G.F. is funded by a Wellcome Trust 4-year PhD studentship in molecular, genetic and life course epidemiology (WT083431MA). The UK Medical Research Council (grant 74882), the Wellcome Trust (grant 076467) and the University of Bristol provide core support ALSPAC. G.F., L.P., J.P.K., N.J.T., G.D.S. and D.M.E. work in a centre that receives funds from the UK Medical Research Council (G0600705) and the University of Bristol. C.J.H. and V.J.W. are funded by European Union's Seventh Framework Programme under EC-GA no. 279185 (EUCLIDS). The research of I.P. is funded through the European Community's Seventh Framework Programme (FP7/2007-2013), ENGAGE project, grant agreement HEALTH-F4-2007-201413. Northern Finland Birth Cohort 1966 (NFBC1966) received financial support from the Academy of Finland (project grants 104781, 120315, 129269, 1114194, 139900/24300796, Center of Excellence in Complex Disease Genetics and SALVE), University Hospital Oulu, Biocenter, University of Oulu, Finland (75617), the European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643), NHLBI grant 5R01HL087679-02 through the STAMPEED programme (1RL1MH083268-01), NIH/NIMH (5R01MH63706:02), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the
