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Chunk #11 — Methods — Imaging protocol and spatial preprocessing of brain images

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Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.
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Data were analyzed with Statistical Parametric Mapping (SPM8, Wellcome Department of Imaging Neuroscience, University College London, U.K.). Images from the first five TRs at the beginning of each session were discarded to enable the signal to achieve steady-state equilibrium between radio frequency pulsing and relaxation. In the pre-processing of BOLD data, images of each participant were realigned (motion-corrected) and corrected for slice timing. A mean functional image volume was constructed for each participant for each run from the realigned image volumes. These mean images were co-registered with the high resolution structural image and then segmented for normalization to an MNI (Montreal Neurological Institute) EPI template with affine registration followed by nonlinear transformation. Finally, images were smoothed with a Gaussian kernel of 8 mm at Full Width at Half Maximum. Images from the first five TRs at the beginning of each trial were discarded to enable the signal to achieve steady-state equilibrium between radio frequency pulsing and relaxation.