We assessed whether hypothesis-driven candidate genes were over-represented for smaller ISC GWAS p-values using ALIGATOR. The central comparison was whether there was an over-representation of the top 5% of significant genes in the hypothesis-driven candidate gene list in comparison to the remaining annotated genes. In Table 2, there was a nominally significant over-representation of smaller p-values in the ISC data for the full set of hypothesis-driven candidate genes but these values did not survive multiple testing correction. In addition, there was no evidence for over-representation of small ISC p-values in the most studied hypothesis-driven candidate genes (≥3 times, 23.1% of the total).
