and rumination–worry–neuroticism. In both categories, the patterns of genetic correlations appear to follow a gradient across disorders and traits. For example, in the compulsivity–impulsivity category, strong positive correlations are seen with anorexia nervosa and Tourette syndrome, which are disorders with strong compulsive features, with less positive associations seen with ADHD and negative correlations with alcohol dependence and risk-taking behaviors, which are all phenotypes characterized by impulsivity. A similar gradient is observed for the rumination–worry–neuroticism-related phenotypes, with strong positive correlations with anxiety and other ruminative phenotypes such as worry, transitioning to less strong correlations with individual depression-related items.
