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Chunk #29 — RESULTS — Post‐multivariate GWAS analyses — Neuroimaging genetic correlation analyses

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Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.
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For rs‐fMRI connectivity phenotypes, there were no FDR‐significant genetic correlations with alcohol consumption or AUD (Table S31). However, sensation seeking was significantly correlated with 17 rs‐fMRI functional connectivity phenotypes, including a global connectivity measure broadly indexing functional connectivity between motor and subcortical‐cerebellar networks (r g = 0.25). To simplify the examination and interpretation of single network measure results, connectivity nodes were manually mapped to a 7‐network parcellation 56 : frontoparietal, visual, limbic, dorsal attention, ventral attention, somatomotor, and default networks. Based on this parcellation, results suggested consistent genetic overlap between sensation seeking and connectivity phenotypes involving somatomotor networks as well as nodes localised to the cerebellum (Table 4).