4 and beta oscillations (Porjesz et al., 2002). Moreover, a GABAA receptor gene encoding the alpha-2 subunit has also been associated with beta oscillations and DSM-IV-TR diagnosis of alcohol dependence (Edenberg et al., 2004). Studies have also shown that gamma oscillations, which are also regulated by GABAergic mechanisms (Whittington et al., 2000), are attenuated in individuals diagnosed with alcohol dependence and at risk for alcohol dependence (Padmanabhapillai et al, 2006a, 2006b). More recently, attenuated evoked-beta band oscillations have been reported in alcohol dependent individuals (Rangaswamy et al., 2007b). While these findings suggest that deficits in beta oscillations and GABAA receptor function are associated with increased risk of alcohol dependence, future studies in B6 and D2 mice could provide a better understanding of the relationship between GABAA receptor function, beta oscillations and the risk of alcohol dependence.
