differences in heavy episodic drinking among married individuals as a function of parental history of alcohol dependence, but there were differences as a function of polygenic risk scores. Thus, although the polygenic risk and parental history models are consistent in demonstrating that the pathogenic gene-by-environment effect decays over time, the inconsistent results across the polygenic risk and parental history models at age 25 caution against any strong conclusions about the exact nature of this decay (and whether the effect observed at age 21 fully reverses).
