using Eq. 12. Thus, in this case, the SMR statistic is slightly smaller than the (top eQTL based) S-PrediXcan \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\chi _1$$\end{document}χ1-square. This reduced significance is accounting for the uncertainty in the eQTL association. As the evidence for eQTL association grows, the denominator \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Z_{\mathrm{eQTL}}^2$$\end{document}ZeQTL2 increases and the difference tends to 0.
