variable was standardized by subtraction of its mean value and division by its standard deviation across all samples. One p53KD-Ras/EGFR/SrciNPC outlier sample was removed from further analysis. Differential expression analysis was carried out using ANOVA in Qlucore Omics Explorer 2.3. Probes with a q value <0.01 were considered differentially expressed. The differentially expressed probes were then clustered using hierarchical clustering and only the probes (n=463) that displayed high correlation between the GTICs and p53KD-Ras/EGFR/SrciNPC samples were displayed in the heatmap. Pathways analysis was performed using IPA software (Ingenuity Systems, build v. 308606 M, content v. 18488943).
