CaMKII is modulated by cannabinoids and opiates. Acute treatment with low doses of THC in rats decreases CaMKII activity in the hippocampus,246 whereas high doses of morphine acutely increase levels of phosphorylated CaMKII in whole mouse brain homogenates.247 Chronic treatment with morphine increases levels of CaMKIIα in rat hippocampal synaptosomes.248
