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Chunk #25 — Discussion

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Independent delta/theta rhythms in the human hippocampus and entorhinal cortex.
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in humans could thus be interpreted such that the entorhinal rhythm may represent intrinsic entorhinal rhythmicity mediated by sensory and other cortical inputs, while the hippocampal rhythm could reflect theta activity generated autonomously within the hippocampus itself, mediated by inputs from the medial septum and the diagonal band of Broca. We may speculate further that the two independent rhythms observed here might represent the two oscillators of slightly different frequencies postulated by the interference model of theta phase precession (O'Keefe and Recce, 1993). To actually test these hypotheses, however, simultaneous recordings of local field potentials and unit activity as well as an improved spatial sampling and more accurate subregional localization of the recording contacts would be necessary.