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Chunk #46 — Discussion

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EEG coherence related to fMRI resting state synchrony in long-term abstinent alcoholics.
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Although our results are encouraging, our analysis is limited. We only analyzed 20 LTAA and 21 NSAC, and our confidence would increase if our results were replicated in a larger sample or independent sample. Also, in this initial attempt to find EEG correlates of rs-fMRI networks, we only examined the magnitude-squared coherence. It is possible that the phase-angle component of coherence carries important information, and future work should consider both amplitude and phase. It is worth pointing out that our resting EEG was acquired with eyes open, in order to minimize the influence of the alpha rhythm that dominates at parietal electrodes during the eyes closed condition, while the rs-fMRI was acquired with eyes closed. It is unclear whether this acquisition difference affected our results. Another limitation is that our rs-fMRI scans are only about 4 min long, while recent work suggests that much longer scans (on the order of 8–12 min) are required for stability and reproducibility of network measurements. These two limitations (eyes closed vs. eyes open and length of EEG and fMRI acquisition) underscore that our major