It was previously reported that CNVs identified in ADHD cases are enriched at loci that harbor CNVs associated with schizophrenia and autism (17). In the present study, we observed that 18 of 460 (3.9%) CNVs >100 kb identified in the case subjects overlapped with one of the 32 loci previously implicated in autism (20), compared with only 20 of 1,102 (1.8%) of the CNVs identified in comparison subjects (p=0.009; Table 3), representing a rate 2.16 times greater in case subjects relative to comparison subjects. We also observed that ADHD case subjects had a 1.49-fold excess of CNVs located at the eight loci previously implicated in schizophrenia relative to comparison subjects (5.4% compared with 3.6%, p=0.03; Table 3). The lists of regions previously implicated in autism and schizophrenia are not independent of each other (they have five regions in common).
