For ALC, the published GWAS are small and no large-scale meta-analysis has been conducted. 93–97 In our opinion, there are clear needs for a high-quality meta-analysis and to increase the number of samples with GWAS data – particularly given that risk profile analysis (Box 3) suggested that larger samples would yield more associations. 97 For alcohol consumption, GWAS in East Asian samples confirmed the role of ALDH2, 98,99 and AUTS2 was implicated in alcohol consumption in European subjects. 100 Using a candidate gene approach, the association of ADH1B with ALC and alcohol consumption was extended to European ancestry subjects. 101
