We first conducted descriptive statistics and correlations between the study variables. We then conducted path analysis using Mplus version 8.3 to examine whether sensation seeking and social support serve as indirect pathways linking alc-GPS to alcohol use (Figure 1, Panel A). In the path model, alc-GPS was specified as exogeneous variables associated with alcohol use directly and indirectly through sensation seeking, family support, and friend support. Sensation seeking, family and friend support were specified as associated with alcohol use. Family and friend support were also specified to be correlated. Age, sex, and genetic ancestry principal components were specified as covariates for sensation seeking, family and friend support, and alcohol use.
