To determine if expression changes in LCLs treated with ethanol mirror changes in the brain and to identify genes with multiple lines of evidence for a relationship to alcohol use disorders, we assembled two sets of data from microarray experiments on rat models of alcoholism. The first dataset was a composite of expression changes in many brain regions (amygdala and central core of the amygdala, nucleus accumbens and nucleus accumbens shell, dorsal raphe nucleus, periaqueductal grey, ventral tegmental area, ventral hippocampus, and medial pre-frontal cortex) of P (alcohol-preferring) rats who had been voluntarily drinking ethanol in various paradigms from 4 to 10 weeks (Bell et al., 2009; McBride et al., 2014; McBride, Kimpel, McClintick, Ding, Hauser, et al., 2013; McBride et al., 2010; McClintick et al., 2015, 2016, 2018; Rodd et al., 2008). The second dataset compiled differences in gene expression in alcohol-naïve animals from pairs of rat lines selected for differences in their voluntary consumption of ethanol (in all cases high drinking lines are listed first): five brain regions from alcohol-naïve inbred P and NP rat hippocampus, amygdala, frontal
