The reference human brain proteomes for the discovery PWAS were profiled from the dorsolateral prefrontal cortex (dPFC) of post-mortem brain samples donated by 400 participants of European descent of the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP)22. ROS/MAP participants provided informed consent, signed an Anatomic Gift Act, and a repository consent to allow their data and biospecimens to be repurposed. The studies were approved by an Institutional Review Board of Rush University Medical Center.
