and stress-activated protein kinase 1 (MSK1)] and ETS-domain protein Elk-1 that are downstream of the ERK/MAPK signaling cascade (143, 145, 147, 148). Conversely, nuclear type 1 protein phosphatase (PP1), a nuclear protein Ser/Thr phosphatase that acts as a universal negative regulator of memory and synaptic plasticity, interfered with H3Ser10phos in several brain areas such as the HPC and the AMG (149–152).
