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Chunk #86 — Materials and methods — Estimation of dispersions

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.
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Additional file 1: Table S2 compares this approximation for the variance of logarithmic dispersion estimates with the variance of logarithmic Cox–Reid adjusted dispersion estimates for simulated negative binomial data, over a combination of different sample sizes, number of parameters and dispersion values used to create the simulated data. The approximation is close to the sample variance for various typical values of m, p and α.