all genes in associated regions are simply lumped together as a single gene set (losing the important distinction that some loci bear many more genes than others). In addition, we added gene sets previously shown to be enriched for genetic variation associated with schizophrenia102, including genes regulated by FMRP (fragile X mental retardation protein) targeting103, predicted targets of miR-137 (filtered to include those with a total context score ≤ 0.3 or an aggregate PCT (probability of conserved targeting) ≥ 0.9 in TargetScan version 6.2)104, voltage-gated calcium channels102, and 5 related subsets of genes whose protein products are localized to the postsynaptic density of neurons, including those involved in glutamatergic neurotransmission105.Hypothesis-free: These gene sets were derived from three widely-used databases for functional gene classification: curated GO (Gene Ontology) sets of molecular functions (MF), biological processes (BP), and cellular components (CC) (http://www.geneontology.org)106; the curated Reactome database of pathways and reactions in human biology (http://www.reactome.org)107; and HGNC (HUGO Gene Nomenclature Committee) gene families (http://www.genenames.org)108.
