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Chunk #13 — Method — Measures — MDD

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Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control.
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The assessment of MDD was a modified version of the depression assessment from the Alcohol Use Disorder and Associated Disabilities Interview Schedule – IV used in the National Epidemiologic Survey of Alcohol and Related Conditions (Grant et al. 2004). To be administered all MDD criteria, individuals had to endorse having experienced a period of at least 2 weeks during which depressed mood or loss of interest/pleasure in daily activities was present. These symptoms were used to create a DSM-5 MDD diagnosis based on a cut-off of endorsing five or more symptoms. Distress, impairment, and exclusionary criteria (e.g. depression due to physical causes) were not assessed, resulting in a broad diagnosis of MDD. About one-third of participants met criteria for MDD (33.0%), and the estimated test–retest reliability was 0.71 based on κ (95% CI 0.59–0.84) and 0.73 based on Y (95% CI 0.60–0.85).