We conclude from this analysis that if only SNPs available through the HapMap project had been chosen to represent the regions sequenced in our candidate genes, we would only have represented 26% of the variants (179/684) that are actually present in our study population ( Figure 1 and Table 4 ). Subsequently, tagSNPs chosen using this combined method were genotyped in 493 healthy oldest old and 439 random individuals aged 40–50, using the Illumina GoldenGate method (data not shown). Only 7 out of 245 (2.4%) private re-sequencing tagSNPs were represented by 297 HapMap tagSNPs at r2 = 0.8.
