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Chunk #48 — Online Methods — Main fine-mapping simulations

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Functionally informed fine-mapping and polygenic localization of complex trait heritability.
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We ran CAVIARBF 0.2.1 with an AIC-based parameter selection, using ridge regression with regularization parameter λ selected from {2−10, 2−5, 2−2.5, 20, 22.5, 25, 100, 1000, 10000, 100000}, with a single locus and with up to either 1 or 2 causal SNPs per locus, owing to computational limitations.