Chunk #20 — RESULTS — Biological annotation:

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Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.

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Regional association plots for the chromosome 3 and chromosome 13 GWS loci from the AA GWAS are presented in Figure 2. The two SNPs on chromosome 3, rs34066662 and rs58801820, are in complete linkage disequilibrium (LD; HapMap AFR sample: r2>0.996; D’=1). There was evidence that one or both of these SNPs were eQTLs for Nephrocystin 3 (NPHP3) in the sigmoid colon (GTEx v6: p = 4E-06) and the adrenal gland (GTEx v7: p = 7E-06; reference expression data primarily drawn from Europeans, see chromatin interactions in Appendix Supplemental Figure S3A).