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Chunk #73 — Review

Source
Genome-wide association studies in ADHD.
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yes

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Additive8.34E-06−1.412.14E-06chr13:28332854 rs1161457 Dominant2.41E-050.952.75E-06chr13:28332854rs11752175Dominant1.17E-050.994.65E-06chr6:39625468Within intron of KIF6Encodes kinesin family member 6, a member of the superfamily of molecular motors that are involved in intracellular transport. Several kinesins have been implicated in the pathogenesis of chronic diseases, including neurodegenerative diseases, type 2 diabetes, and Alzheimer’s disease. The finding falls into a suggestive linkage region for schizophrenia from meta-analysis and several primary studies (Lewis et al. 2003), as well as being close to a suggestive linkage finding from meta-analysis in ADHD (Zhou et al. 2008c). KIF6 also shows association with schizophrenia in GWAS (Sullivan et al. 2008) at P values of 10−4 rs4714261 Dominant9.41E-060.952.03E-06chr6:39647185 rs4714261 Additive1.36E-05−1.304.10E-06chr6:39647185rs2360997Additive6.32E-05−1.307.79E-06chr14:75882244Within 25 upstream of ESRRBEncodes estrogen-related receptor beta, a protein with similarity to the estrogen receptor, expressed in brain and other tissues. Mutations in the gene cause non-syndromal hearing loss (Collin et al. 2008). Was also found in CNV study in autism (Marshall et al. 2008)rs10049246Additive3.25E-050.608.09E-06chr3:187169435Within intron of AK309325Hypothetical gene of unknown function. Finding lies in linkage region for autism (Allen-Brady et al. 2008)rs4875598Dominant1.31E-05−0.948.91E-06chr8:5449161IntergenicFinding lies in suggestive linkage region for ADHD from meta-analysis (Zhou et al. 2008c)Site is known for CNVsValues indicated in bold are SNPs that appear in the list more than once aWhere not indicated otherwise,