To summarize, our commentators have made a number of valuable suggestions that represent possible reasons for our lack of significant findings and strategies to implement in the future that may yield discoveries. It is worth noting that our knowledge of psychiatric genetics remains very much in its infancy—very much a world of “unknown unknowns.” Thus, as Patrick (2014, this issue) points out, publication of both positive and negative findings (i.e., considering all available information) is required before conclusions of any sort are warranted.