Salient subject demographics, alcohol consumption, severity and craving parameters by medication and OPRM1 group are provided in table 1. The groups were generally well-balanced on all key variables with few significant differences. There was about 2:1 males to females with on average several years of college education. Overall, subjects drank heavily in a bit over 50% of the days prior to randomization and had 8-10 drinks per drinking day on average with ADS and OCDS scores in the mild to moderate range. In general this reflects the demographics of the wider population who were screened for study inclusion.
