Postmortem tissue from schizophrenia (SCZ) and bipolar or other affective/mood disorder (AFF) cases were included if they met the appropriate diagnostic DSM-IV criteria, as determined in consensus conferences after review of medical records, direct clinical assessments, and interviews of family members or care providers. Cases were excluded if they had neuropathology related to Alzheimer’s disease and/or Parkinson’s disease, acute neurological insults (anoxia, strokes, and/or traumatic brain injury) immediately prior to death, or were on ventilators near the time of death. Three case samples (2 with leukotomies, and 1 with a history of a head injury prior to diagnosis) were included; these were not outliers on any metrics that we used to evaluate our samples (see “RNA-seq outliers” below).
