Due to the expression profile of SLCA615 and its presumed role in neuronal amino acid transport and glutamate synthesis (Broer et al., 2006) and due to reported hippocampal volume changes in MD (Frodl et al., 2002; Videbech and Ravnkilde, 2004), we investigated both volumetric and 1H-NMR-spectroscopy (1H-NMR) markers of hippocampal integrity and signalling in subsamples of the Southern German discovery and replication samples (for sample see supplemental methods).
